SELECTIVE RNAI SILENCING OF SCHWANN CELL PIEZO1 ALLEVIATES MECHANICAL HYPERSENSITIZATION FOLLOWING PERIPHERAL NERVE INJURY

Selective RNAi silencing of Schwann cell Piezo1 alleviates mechanical hypersensitization following peripheral nerve injury

The present study was designed to investigate the role of Schwann cell (SC) Piezo1 in peripheral nociception.We first developed an AAV vector that has primary SC tropism after delivery into the sciatic (or tibial) nerve.This was achieved by packing AAV-GFP transcribed by not as lean still a marine shirt a CBA promoter using a capsid AAVolig001 to g

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Metabolomic Analysis of Cricket paralysis virus Infection in Drosophila S2 Cells Reveals Divergent Effects on Central Carbon Metabolism as Compared with Silkworm Bm5 Cells

High-throughput approaches have opened new opportunities for understanding biological processes such as persistent virus infections, which are widespread.However, the potential of persistent infections to develop towards pathogenesis remains to be investigated, particularly with respect to the role of host metabolism.To explore the interactions bet

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Automated Breast Tumor Detection and Segmentation Using the Threshold Density Algorithm with Logistic Regression on Microwave Images

Context: Breast cancer remains a major health burden worldwide, necessitating improved screening modalities for early detection.However, existing techniques such as mammography and MRI exhibit limitations regarding sensitivity and specificity.Microwave imaging has recently emerged as a promising technology for breast cancer diagnosis, exploiting th

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